Montelukast to prevent rituximab infusion reactions

[Alison Shipley]

Hi,

A number of our patients have experienced rituximab-associated infusion reactions.  These patients all received the standard pre-medications (methylprednisolone 100 mg IV, diphenhydramine 50 mg PO, acetaminophen 500 mg).  Rituximab has been reconstituted as per product monograph and the infusion titrated according to the 255-minute protocol.

We are interested to know the experience at other centers and whether different pre-medications are being prescribed. We are considering using montelukast.

Any thoughts are welcome!

Thank you,

Alison

[Jennifer Lowry]

Hi Alison,

Here at Grand River Hospital we have been promoting Montelukast 10mg the night before & 10mg the morning of the infusion on the recommendation of our oncology pharmacists with great success.  All the other pre-meds are the same as well.

Regards,

Jennifer

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